Calcium Glycerophosphate USP BP Ph Eur FCC Food Grade Manufacturers

Anmol Chemicals is Group, established in 1976, is the pioneer manufacturer of Calcium Glycerophosphate USP BP Ph Eur FCC Food Grade. It has (FDA) GMP-GLP approval, ISO-9001 Certificate, "REACH" Pre-registration, ISO-22000 HACCP, Kosher Certificate and Halal Certificate.

Calcium Glycerophosphate USP BP Ph Eur FCC Food Grade Manufacturers

Specifications of Calcium Glycerophosphate USP Dietary Supplement Grade:
C3H7CaO6P --- 210.14
1,2,3-Propanetriol, mono(dihydrogen phosphate) calcium salt (1:1);
Calcium glycerophosphate CAS 27214-00-2.

DEFINITION
Calcium Glycerophosphate is a mixture, in variable proportions, of calcium (RS)-2,3-dihydroxypropyl phosphate and calcium 2-hydroxy-1-(hydroxymethyl)ethyl phosphate, which may be hydrated. ;Calcium Glycerophosphate contains NLT 18.6% and NMT 19.4% of calcium Ca), calculated on the dried basis.

IDENTIFICATION
A.
Analysis: Ignite 0.1 g in a crucible. Take up the residue with 5 mL of nitric acid, heat on a water bath for 1 min, and filter. Mix 1 mL of the filtrate with 2 mL of ammonium molybdate.
Acceptance criteria: A yellow color develops.
B.
Analysis: Dissolve 20 mg of the substance being examined in 5 mL of 5 M acetic acid and add 0.5 mL of potassium ferrocyanide solution (53 mg/mL). The resulting solution remains clear. To the clear solution, add 50 mg of ammonium chloride.
Acceptance criteria: A white crystalline precipitate is produced.

Specifications of Calcium Glycerophosphate FCC Food Grade
C3H7CaO6P Formula wt 210.14
CAS: 27214-00-2

DESCRIPTION
Calcium Glycerophosphate occurs as a fine, white powder. It is somewhat hygroscopic. One gram dissolves in about 50 mL of water at 25C. It is more soluble in water at a lower temperature, and citric acid increases its solubility in water. It is insoluble in alcohol.
Function: Nutrient.

REQUIREMENTS
Identification: A saturated sample solution gives positive tests for Calcium.
Assay: Not less than 98.0% and not more than 100.5% of C3H7CaO6P, after drying.
Alkalinity: Passes test.
Lead: Not more than 4 mg/kg.
Loss on Drying: Not more than 12.0%.

Specifications of Calcium Glycerophosphate BP Ph Eur
C3H7CaO6P -- 210.1 -- CAS 27214-00-2
Action and use: Excipient.

DEFINITION
Mixture in variable proportions of the calcium salt of 2,3-dihydroxypropyl phosphate and of 2-hydroxy-1-(hydroxymethyl)ethyl phosphate which may be hydrated.
Content: 18.6 per cent to 19.4 per cent of Ca (dried substance).

CHARACTERS
Appearance: White or almost white powder, hygroscopic.
Solubility: Sparingly soluble in water, practically insoluble in ethanol (96 per cent).

IDENTIFICATION
A. Mix 1 g with 1 g of potassium hydrogen sulphate in a test tube fitted with a glass tube.Heat strongly and direct the white vapour towards a piece of filter paper impregnated with a freshly prepared 10 g/l solution of sodium nitroprusside. The filter paper develops a blue colour in contact with piperidine.
B. Ignite 0.1 g in a crucible. Take up the residue with 5 ml of nitric acid and heat on a water-bath for 1 min. Filter. The filtrate gives reaction of phosphates.
C. It gives reaction of calcium.

TESTS
Solution S: Dissolve 1.5 g at room temperature in carbon dioxide-free water prepared from distilled water and dilute to 150 ml with the same solvent.
Appearance of solution: Solution S is not more opalescent than reference suspension.
Acidity or alkalinity: To 100 ml of solution S add 0.1 ml of phph solution. Not more than 1.5 ml of 0.1 M hydrochloric acid or 0.5 ml of 0.1 M sodium hydroxide is required to change the colour of the indicator.
Citric acid: Shake 5.0 g with 20 ml of carbon dioxide-free water and filter. To the filtrate add 0.15 ml of sulphuric acid and filter again. To the filtrate add 5 ml of mercuric sulphate solution and heat to boiling. Add 0.5 ml of a 3.2 g/l solution of potassium permanganate and again heat to boiling. No precipitate is formed.
Glycerol and ethanol (96 per cent)-soluble substances: Maximum 0.5 per cent. Shake 1.000 g with 25 ml of ethanol (96 per cent) for 1 min. Filter. Evaporate the filtrate on a water-bath and dry the residue at 70C for 1 h. The residue weighs a maximum of 5 mg.
Chlorides: Maximum 500 ppm.
Phosphates: Maximum 400 ppm.
Sulphates: Maximum 0.1 per cent, determined on solution S.
Arsenic: Maximum 3 ppm.
Iron: Maximum 50 ppm, determined on 0.20 g.
Heavy metals: Maximum 20 ppm.
Loss on drying: Maximum 12.0 per cent, determined on 1.000 g by drying in an oven at 150C for 4 h.

For an exhaustive Write-up on Calcium Glycerophosphate Manufacture, Specifications, Uses, Applications, MSDS etc. you may write to us:

Calcium Glycerophosphate USP BP Ph Eur FCC Food Grade manufacturer at:

Anmol Chemicals
S-8, SARIFA MANSION, 2ND FLANK ROAD, CHINCHBUNDER, MUMBAI 400009, INDIA
TEL: (OFFICE) 91-22-23770100, 23726950, 23774610, 23723564. FAX: 91-22-23728264

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